
FKBP12 PROTAC dTAG-7
CAS No. 2064175-32-0
FKBP12 PROTAC dTAG-7( dTAG-7 )
Catalog No. M13208 CAS No. 2064175-32-0
FKBP12 PROTAC dTAG-7 (dTAG-7) is a cell-permeable heterobifunctional adation tag (dTAG) small molecule that engage FKBP12F36V and CRBN.
Purity : >98% (HPLC)






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Biological Information
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Product NameFKBP12 PROTAC dTAG-7
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NoteResearch use only, not for human use.
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Brief DescriptionFKBP12 PROTAC dTAG-7 (dTAG-7) is a cell-permeable heterobifunctional adation tag (dTAG) small molecule that engage FKBP12F36V and CRBN.
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DescriptionFKBP12 PROTAC dTAG-7 (dTAG-7) is a cell-permeable heterobifunctional adation tag (dTAG) small molecule that engage FKBP12F36V and CRBN, selectively degrade FKBP12F36V in a CRBN-dependent manner in cells; causes rapid degradation of nuclear and cytoplasmic FKBP12F36V fusion chimeras.
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In Vitro——
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In Vivo——
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SynonymsdTAG-7
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PathwayPROTACs
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TargetPROTAC
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RecptorPROTAC
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Research Area——
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Indication——
Chemical Information
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CAS Number2064175-32-0
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Formula Weight1210.341
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Molecular FormulaC63H79N5O19
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 150 mg/mL (123.93 mM)
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SMILESCCC(C1=CC(=C(C(=C1)OC)OC)OC)C(=O)N2CCCCC2C(=O)OC(CCC3=CC(=C(C=C3)OC)OC)C4=CC=CC=C4OCC(=O)NCCCOCCOCCOCCCNC(=O)COC5=CC=CC6=C5C(=O)N(C6=O)C7CCC(=O)NC7=O
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Chemical Name(1R)-3-(3,4-dimethoxyphenyl)-1-(2-((19-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)-2,18-dioxo-7,10,13-trioxa-3,17-diazanonadecyl)oxy)phenyl)propyl (2S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Nabet B, et al. Nat Chem Biol. 2018 May;14(5):431-441.
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